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SAMHSA-Compliant LC/MS/MS Analysis of Amphetamines in ...The new SAMHSA confirmation cutoff concentration for all amphetamines is 250 ng/mL and a limit of detection at 10% of the cutoff concentration is 25 ng/mL [1]. Because high concentrations of amphetamines can be expected in some urine samples, we chose to use a higher capacity 3 mm id Agilent Poroshell 120 column instead of a 2 mm id column forMon, 28 Oct 2019 20:40:00 GMT
SAMHSA-Compliant LC/MS/MS Analysis of Amphetamines in ...SAMHSA-Compliant LC/MS/MS Analysis of Amphetamines in Urine with Agilent Bond Elut Plexa PCX and Agilent Poroshell 120 Irina Dioumaeva, John M. Hughes Agilent Technologies, Inc.Thu, 17 Oct 2019 18:02:00 GMT
Validation of SAMHSA Guideline Compliant LC-MS Method for ...LC-MS Conditions LC-MS analysis was performed on an Exactive high performance benchtop mass spectrometer coupled with a Thermo Scientific Transcend TLX system. Full scan mass spectrometry analysis with resolution of 100,000 and exact mass for compound the urine matrix, especially for the early eluting compounds, such as morphine and codeine. 20 1.4Fri, 01 Nov 2019 18:27:00 GMT
SAMHSA-Compliant LC/MS/MS Analysis of Opiates (Morphine ...SAMHSA-Compliant LC/MS/MS Analysis of Opiates (Morphine and Codeine) in Urine with Agilent Bond Elut Plexa PCX and Agilent Poroshell 120 Authors Irina Dioumaeva, John M. Hughes Agilent Technologies, Inc. Application Note Forensics & Drug Testing Abstract New guidelines from the US Substance Abuse and Mental Health ServicesMon, 28 Oct 2019 07:47:00 GMT
Hair Analysis for Drugs - SAMHSASimultaneous analysis of six amphetamines and analogues in hair, blood and urine by LC-ESI-MS/MS. Application to the determination of MDMA after low ecstasy intake. • Detection of MDMA in a forensic case • Single administration of ecstasy to a 16-year-old female without her knowledge during a party • Hair collected 60 days after incident •Fri, 01 Nov 2019 14:52:00 GMT
Simultaneous Screening and Quantitation of Amphetamines in ...of Amphetamines in Urine by On-line SPE-LC/MS Method Introduction Amphetamines belong to stimulant drugs and are also controlled as illicit drugs worldwide. The conventional analytical procedure of amphetamines in human urine includes initial immunological screening followed by GCMS con˜rmation and quantitation [1]. With new SAMHSAThu, 17 Oct 2019 16:29:00 GMT
SAMHSA-Compliant LC/MS/MS Analysis of Benzoylecgonine in ...SAMHSA-Compliant LC/MS/MS Analysis of Benzoylecgonine in Urine with Agilent Bond Elut Plexa PCX and Agilent Poroshell 120 Irina Dioumaeva, John M. Hughes Agilent Technologies, Inc. Application Note Forensic Toxicology Abstract New guidelines from the US Substance Abuse and Mental Health Services Administration (SAMHSA), effective October 2010,...Thu, 17 Oct 2019 22:48:00 GMT
SAMHSA-Compliant LC/MS/MS Analysis of Benzoylecgonine in ...LC/MS/MS methods [5]. The extraction procedure and the LC/MS/MS measurement were performed for five replicates of negative urine spiked pre-extraction at the cutoff level, and five replicates of negative urine extract reconstituted in initial mobile phase and then fortified at 100 ng/mL with benzoylecgonine (spiked post-SPE ). The third measurementWed, 23 Oct 2019 17:33:00 GMT
SAMHSA-Compliant LC/MS/MS Analysis of Phencyclidine in ...SAMHSA-Compliant LC/MS/MS Analysis of Phencyclidine in Urine with Agilent Bond Elut Plexa PCX and Agilent Poroshell 120. Irina Dioumaeva, John M. Hughes Agilent Technologies, Inc. Application Note. Forensic Toxicology . AbstractThu, 17 Oct 2019 22:55:00 GMT
Bourland practical aspects of drug testing in ... - SAMHSA• Extraction for GC/MS, GC/MS/MS or LC/MS/MS • Pre-Analytical Process should include Wash Procedure(s) to remove sources of external contamination • Two main approaches • Digestion of the hair matrix to a liquid • Pre-Extraction of the Drug dissolved in a liquid • Challenges • Drugs and metabolites must remain intactSun, 29 Sep 2019 18:23:00 GMT
Quantitation of Benzoylecgonine in Urine for SAMHSA ...opiates, amphetamines, cocaine (benzoylecgonine), cannabis (THCA), and phencyclidine (PCP). Per SAMHSA requirements, these five groups are screened with immunoassays and, in the past, confirmed by gas chromatography/mass spectrometry (GC/MS). In October 2010, SAMHSA approved the use of liquid chromatography/mass spectrometry (LC/MS) forWed, 23 Oct 2019 03:28:00 GMT
Quantitation of Amphetamines in Urine forSAMHSA Mandated ...Quantitation of Amphetamines in Urine for SAMHSA Mandated Workplace Drug Testing Using a Triple Stage Quadrupole LC-MS System. Kristine Van Natta, Marta Kozak; Thermo Fisher Scientific, San Jose, CA. Application Note: 561.Sun, 27 Oct 2019 02:48:00 GMT
Rapid Screening of Amphetamine Drugs in Urine by Positive ...1000 ng/mL. This LC/MS/MS method is very sensitive and can be possibly adapted to other body fluid analysis for amphetamines, such as sweat and oral fluid which have confirmatory drug cutoff levels of 25 ng/mL and 50 ng/mL, respectively. Conclusion The LC/MS/MS method described in this application note is simple and sensitive.Fri, 18 Oct 2019 01:26:00 GMT
Confirmation by Triple Quadrupole LC/MS/MS for Federally ...Confirmation by Triple Quadrupole LC/MS/MS for HHS-compliant Workplace Urine Drug Testing A complete applications solution for forensic toxicology laboratories John Hughes Agilent Technologies Pleasanton, CA Paul Moorman South Bend Medical Foundation South Bend, IN. SAMHSA_Oct2010 LCMSMS confirmation ver5 notes.pptx. Page 1. For Forensic UseWed, 23 Oct 2019 17:40:00 GMT
LC-MS/MS Chiral Separation of “d” and “ ” Enantiomers of ...p 2 RUO-MKT-02-0403-A. glycopeptide-based chiral LC column for the separation of the amphetamine and methamphetamine enantiomers. Experimental Urine was spiked with racemic amphetamine and methamphetamine at concentrations of 1, 2, 4, 8, 40, 200, 1000, 5000, 25 000 ng/mL in order to prepare the calibrators.Mon, 21 Oct 2019 00:03:00 GMT
SAMHSA-Compliant LC/MS/MS Tetrahydrocannabinol in Urine ...SAMHSA-Compliant LC/MS/MS Analysis of 11-nor-9-carboxy-D9-Tetrahydrocannabinol in Urine with Agilent Bond Elut Plexa PCX and Agilent Poroshell 120 Authors Irina Dioumaeva, John M. Hughes Agilent Technologies, Inc. Application Note Forensic Toxicology Abstract Guidelines from the US Substance Abuse and Mental Health Services AdministrationFri, 18 Oct 2019 21:35:00 GMT
Drug Screening E-Compendium - howtouseubiquityBond Elut Plexa PCX Amphetamines SAMHSA-Compliant LC/MS/MS Analysis of Amphetamines in Urine with Agilent Bond Elut Plexa PCX and Agilent Poroshell 120 ... Bond Elut Plexa PCX Morphine/Codeine SAMHSA-Compliant LC/MS/MS Analysis of Opiates (Morphine and Codeine) ... Drug Screening E-Compendium. howtouseubiquity.Sun, 27 Oct 2019 23:48:00 GMT
Cut-off Concentrations Analytes Stability - SAMHSASimultaneous analysis of six amphetamines and analogues in hair, blood and urine by LC-ESI-MS/MS. Application to the determination of MDMA after low ecstasy intake. Detection of MDMA in a forensic case Single administration of ecstasy to a 16-year-old female without her knowledge during a party Hair collected 60 days after incidentSat, 02 Nov 2019 02:05:00 GMT
Drug Test Cut Off Levels - National Drug ScreeningThe laboratory analysis measures the amount of the drug metabolite in the specimen at the time of testing. Using the established cut off level means that a small trace of the metabolite may be present in a specimen and the test result reported as negative. ... (GC-MS) or liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). The ...Thu, 24 Oct 2019 08:42:00 GMT
Chiral LC/MS Analysis of Methamphetamine in Urine on Astec ...Chiral LC/MS Analysis of Methamphetamine ... compliance. All specimens were stored at -4 °C and thawed on the morning prior to analysis. For analysis by chiral LC-MS/MS, samples were processed as follows: To a 125 µL aliquot was added 1 mL of diethyl ether. The diluted sample was vortexed for 30 minutes andMon, 07 Oct 2019 15:50:00 GMT
Quantitation of Amphetamine-Type Stimulants by LC-MS/MS ...Amphetamines or amphetamine-type stimulants ... This chapter describes an LC-MS/MS technique for the analysis of 14 ATSs in blood, serum/plasma, and urine. The method is quantitative and has reporting limits in the low ng/mL range. Electrospray ionization is used in the positive ion mode. Two transitions for each compound are monitored along ...Tue, 01 Oct 2019 02:36:00 GMT
Analytical Considerations When Developing an LC-MS/MS ...Background: While validation of analytical (LC-MS/MS) methods has been documented in any number of articles and reference texts, the optimal design and subsequent validation of a method for over 30 analytes presents special challenges. Conventional approaches to calibration curves, controls, and run time are not tenable in such methods. This report details the practical aspects of designing ...Fri, 01 Nov 2019 17:22:00 GMT
Interpretation of Drug Testing Results in Medication ...Two-Step Testing Approach screening test –designed to separate negative samples from samples that are “presumptively”positive on-site screening devices lab/court-based screening instrumentation confirmation test –lab-based follow-up procedure designed to validate positive test results GC/MS LC/MS/MS why can’t you adjudicate based on the screening testWed, 23 Oct 2019 18:59:00 GMT
Chiral LC-MS Analysis of Methamphetamine in Urine | Sigma ...Chiral LC-MS Analysis of Methamphetamine in Urine on Astec ® CHIROBIOTIC ® V2 By: Marc D. Julliard, Jason E. Strull, Dylan M. Stone, David S. Bell , Reporter US Volume 31.2 Differentiation of Illicit D-Methamphetamine from Over-the-Counter L-Methamphetamine by LC-MSWed, 30 Oct 2019 03:06:00 GMT
Chiral analysis of amphetamines in hair by liquid ...A differentiation between the use of the medically prescribed drug and the abuse of illicit street amphetamine is of great importance, for example in retrospective consumption monitoring by hair analysis. A liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the chiral separation and quantitation of (S)‐ and (R)‐AMP in ...Sun, 13 Oct 2019 14:03:00 GMT
Methamphetamine Urine Toxicology: An In-depth ReviewIf no amphetamines are detected, then the amphetamine result is negative and no further testing is needed. If only amphetamine is detected, once again no further testing is needed. A finding of amphetamine-only positive by MS can be caused by prescription drugs (Adderall and various amphetamine salts) or as a result of methamphetamine ...Mon, 04 Mar 2019 23:57:00 GMT
LC-MS:apowerfultoolinworkplacedrug testingMS based confirmation methods do not enable the detection of low levels of drugs. Consequently the more sensitive LC-MS(MS) appears to be a prerequisite if the desired sensitivity is to be attained. Lc-Ms(Ms) A dramatic increase in the capabilities of mass spectrometry (MS) has been seen in the last 20years, and its coupling to liquidTue, 22 Oct 2019 22:28:00 GMT
Quantitative Confirmatory Analysis of the NIDA 5 Panel ...confirmatory analysis. LC-MS/MS methods are often less complicated than the previously implemented GC-MS/MS methods because they do not require derivatization. The NIDA-5 panel requires 6 separate quantitative methods for analysis of THCA, opiates, amphetamines, cocaine, phencyclidine and 6-MAM to confirm immunomethod positive samples.Fri, 25 Oct 2019 12:52:00 GMT
Interpretation of Pain Management Testing Results Using ...Despite the known inferiority of IA compared with LC-MS/MS testing, current government and private payment models do not support the use of only LC-MS/MS testing for all patients . The purpose of this review is to describe how patient medication compliance is evaluated using a case-based approach.Fri, 01 Nov 2019 15:42:00 GMT
Medical Review Officer Manual - samhsa.govThe MS creates charged particles (ions) and separates them according to their mass-to-charge (m/z) ratios. The ions form unique mass spectra, which are used to identify analytes. Urine specimens must undergo a specimen preparation process (i.e., extraction) prior to GC/MS analysis and may require preparation prior to LC/MS analysis.Wed, 23 Oct 2019 20:46:00 GMT
Quantitation of Phencyclidine in Urine for SAMHSA-Mandated ...opiates, amphetamines, cocaine (benzoylecgonine), cannabis (THCA) and phencyclidine (PCP). Per SAMHSA requirements, these five groups are screened with immunoassays and, in the past, confirmed by gas chromatography/mass spectrometry (GC/MS). In October 2010, SAMHSA approved the use of liquid chromatography/mass spectrometry (LC/MS) forSat, 02 Nov 2019 01:58:00 GMT
Confirmation of multiple drugs in oral fluid using LC-MS/MSConfirmation of multiple drugs in oral fluid using LC-MS/MS Cynthia Coulter, Margaux Garnier, James Tuyay, Christine Moore Immunalysis Corporation, Pomona, CA, U.S.A. •In 2011 the Drug Testing Advisory Board recommended to the Substance Abuse and Mental Health Service Administration (SAMHSA) that oral fluid be allowed as a specimen in the FederalWed, 25 Sep 2019 12:08:00 GMT
Simultaneous Liquid Chromatography–Mass Spectrometry ...Of interest is the differential pattern of opiate and cocaine biomarkers observed after LC–MS as compared to gas chromatography–mass spectrometry analysis. Introduction Illicit drug use is increasing worldwide with millions of individuals reporting cocaine, heroin, amphetamines, cannabis, and other drug use, all which substantially affect ...Mon, 02 Jan 2017 01:46:00 GMT
Extraction and LC/MS/MS Analysis of Amphetamines from ...Extraction and LC/MS/MS Analysis of Amphetamines from Human Urine application note. 1. For additional technical notes, visit www.phenomenex.com Page 1 of 2 APPLICATION Extraction and LC/MS/MS Analysis of Amphetamines from Human Urine Using Strata® -X-C Microelution 96-Well Solid Phase Extraction (SPE) Plates and a Kinetex® 2.6 µm Biphenyl Core-Shell HPLC Column Shahana Huq and Matthew ...Wed, 25 Sep 2019 00:34:00 GMT
Rapid Analysis of Amphetamines in Biological Samples | LCGCThis study demonstrates a faster method of analysis when coupling a simplified and effective SPE procedure with a core-shell HPLC column and LC–MS-MS detection. Recently, the Substance Abuse and Mental Health Services Administration (SAMHSA) has lowered the amphetamine drug class cutoff level and has added MDMA, MDA, and MDEA to the panel.Wed, 11 Sep 2019 18:23:00 GMT
Differentiating Medicinal from Illicit Use in Positive ...This retrospective analysis included the LC-MS/MS results and prescriber provided medication histories of 485,889 de-identified urine specimens from patients treated for pain. Two groups of 100 specimens each were subjected to chiral analysis. Group 1 contained specimens that were MAMP positive and amphetamine negative.Wed, 30 Oct 2019 02:59:00 GMT
Development and Validation of Direct Analysis Method for ...LC/MS/MS method for direct analysis of amphetamines in urine without sample pre-treatment (except dilution with water) on LCMS-8040, a triple quadrupole system featured as ultra fast mass spectrometry (UFMS).Thu, 17 Oct 2019 16:29:00 GMT
Oral Fluid Testing for Drugs of AbuseOral fluid (OF) is an exciting alternative matrix for monitoring drugs of abuse in workplace, clinical toxicology, criminal justice, and driving under the influence of drugs (DUID) programs. During the last 5 years, scientific and technological advances in OF collection, point-of-collection testing ...Tue, 24 Jan 2017 09:19:00 GMT
When Hospital Toxicology Report Is Negative in a Suspected ...Over the last decade LC–MS or preferably LC–MS/MS has been established as the most reliable methodology in toxicology laboratories for analysis of drugs of abuse as well as therapeutic drugs. In contrast to the “Gold Standard” of the past 30+ years, namely GC–MS, LC–MS/MS has enhanced the confirmation processes by a factor of 5.Thu, 17 Oct 2019 06:42:00 GMT
practical aspects of hair drug testing Bourland DTAB 7Extraction for GC/MS, GC/MS/MS or LC/MS/MS ... 126 requests for directed analysis for THC in children’s hair ... practical aspects of hair drug testing Bourland DTAB 7.13 Author: HHS/SAMHSA/CSAP/DWP Subject: practical hair drug testing DTAB 7.13 Bourland Keywords:Wed, 30 Oct 2019 15:02:00 GMT
TN-0053 APPLICATIONS - PhenomenexHealth Services Administration (SAMHSA). 2010 Table 1 Compound Classification of 41 Pain Management Drugs Analysis was performed using an Agilent® 1100 LC system (Agilent Technologies, Palo Alto, CA, USA) coupled with an API 5000™ LC/MS/MS detector (AB SCIEX, Framingham, MA, USA).Wed, 02 Oct 2019 06:45:00 GMT
Table of Contents - Nxtbook MediaBond Elut Plexa PCX Amphetamines SAMHSA-Compliant LC/MS/MS Analysis of Amphetamines in Urine with Agilent Bond Elut Plexa PCX and Agilent Poroshell 120 (5990-9623EN) Bond Elut Plexa PCX Benzoylecgonine SAMHSA-Compliant LC/MS/MS Analysis of Benzoylecgonine in Urine with Agilent Bond Elut Plexa PCX and Agilent Poroshell 120 (5990-9624EN)Wed, 23 Oct 2019 18:52:00 GMT
Clinical ResearchA majority of forensic testing involves the analysis of samples for workplace drug testing, court cases, monitoring rehab patients, and cause of death. LC/MS/MS and SPE are essential tools in this work, where the ability to analyze low levels of compounds is so important.Fri, 18 Oct 2019 00:28:00 GMT
Thermo Fisher :: Orbitrap :: NIDA-5It uses full-scan MS at 70,000 to 100,000 FHWM resolution. The LC-MS analysis quantifies the following panel of compounds: amphetamines, methamphetamine, MDA, MDMA, MDEA, BE, THCA, PCP, Morphine, Codeine, and 6MAM. The methodology presented here meets all SAMHSA method validation guidelines.Thu, 17 Oct 2019 15:53:00 GMT
DDRUGS OF ABUSE ANALYSIS RUGS OF ABUSE ANALYSIS ...dilution of the urine sample, followed by liquid chromatography–tandem mass spectrometry (LC/MS/MS) analysis. Chromatographic separation was achieved using an Atlantis® dC 18 column, eluted with a mixture of formic acid and metha-nol. The method was linear from 1–80 mg/L for GHB and 1,4-BD and from 1–50 mg/L for GBL.Sun, 27 Oct 2019 21:32:00 GMT
TROUBLESHOOTING GUIDE DRUGS OF ABUSEChromatography/mass spectrometry (GC/MS) is the preferred confirmatory method, but the use of Liquid Chromatography/mass spectrom etry (LC/MS) for confirmation testing is increasing. Clinical consideration and professional judgment should be applied to any drug of abuse test result, particularly when preliminary results are indicated.Mon, 28 Oct 2019 18:53:00 GMT
Analysis of an Expanded Panel of Sympathomimetic Amines in ...A method was developed to demonstrate the performance of the ISQ GC–MS system for the analysis of five amphetamines in a urine matrix. The extended amphetamines assay described offers broad linearity to cover a wide range of analyte concentrations, with R 2 values of 0.9990 or higher for all analytes over the range of 25–25,000 ng/mL in sample.Wed, 09 Oct 2019 05:40:00 GMT
University of Groningen The influence of the sample matrix ...GC-MS and require extensive sample preparation with, for example, solid phase extraction (SPE) and derivatization [11, 13, 16, 21, 22]. Only one article described sweat patch analysis of multiple substances performed with LC-MS/MS, but this analysis still used an extensive sample preparation with SPE [23].Tue, 29 Oct 2019 04:11:00 GMT
Frequently Asked Questionsutilizes a liquid phase for specimen separation in conjunction with the mass analysis ability of Mass Spectrometry (MS) to provide definitive identification of the drug. Similar to GC-MS/MS, LC-MS/MS or “LC-tandem MS” generally provides greater sensitivity, which may be necessary for the analysis of alternative specimens, such as hair or ...Mon, 28 Oct 2019 12:34:00 GMT
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